Search results for " amniotic membrane"

showing 3 items of 3 documents

Recent Advances in Derivation of Functional Hepatocytes from Placental Stem Cells

2013

Abstract: End-stage liver diseases are one of the leading causes of death in the world. Often orthotopic liver transplantation represents the final therapeutic choice. The limits of this approach are the scarcity of donor livers available, and the many side effects related to the administration of immune suppressants to the patients. Cellular therapy for liver diseases is increasingly being viewed as a promising strategy to provide hepatocytes to replenish the parenchymal cells of the organ. This technique suffers of some important limitations, such as the difficulty in isolating sufficient cell numbers (e.g. when adult or foetal hepatocytes are used for transplantation), the limited viabil…

Hepatocyte differentiationMesenchymal stem cells Wharton’s jelly amniotic fluid amniotic membrane immune modulation umbilical cord hepatocyte differentiation functional assays inflammation fibrosis regenerative medicine tissue repair.Settore BIO/16 - Anatomia UmanaMesenchymal stem cellBiologyPlacenta cord bankingRegenerative medicineCell therapySettore MED/38 - Pediatria Generale E Specialisticamedicine.anatomical_structureDevelopmental NeuroscienceImmunologyCancer researchmedicineBone marrowStem cellDevelopmental BiologyAdult stem cellThe Open Tissue Engineering and Regenerative Medicine Journal
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The Immunomodulatory Features of Mesenchymal Stromal Cells Derived from Wharton’s Jelly, Amniotic Membrane, and Chorionic Villi In Vitro and In Vivo …

2016

This chapter focuses on the immunomodulatory properties of placental mesenchymal stromal cells (MSCs) derived from the amniotic membrane, umbilical cord, and chorionic villi. Within the amniotic membrane (AM), we discuss the immunomodulatory properties of the two main cell populations that can be isolated from AM: human amniotic mesenchymal stromal cells (hAMSCs) and human amniotic epithelial cells (hAECs). Within the umbilical cord, several compartments have been described, including the amniotic compartment, the Wharton’s jelly (WJ) compartment, and the vascular and perivascular compartment, but herein attention is focused on the properties of human WJ MSCs (hWJMSCs). Since different isol…

Settore BIO/17 - IstologiaWharton’s JellyUmbilical cord Wharton's jelly placenta mesenchymal stromal cells stem cells chorionic villi amniotic membrane regenerative medicine differentiation immeune modulationSettore BIO/16 - Anatomia UmanaSettore BIO/13 - BIOLOGIA APPLICATA
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Perinatal stem cells revisited: directions and indications at the crossroads between tissue regeneration and repair.

2013

Perinatal stem cells research attracted great interest worldwide in recent years. Foetus-associated tissues contain various populations of stem cells, most of which are comprised within the category of mesenchymal stem cells (MSCs). This special issue collects both reviews and original reports on all the perinatal stem cell types which are currently under investigation. These cells have multiple promising features: differentiative capacity towards mature cell types of all the three germ layers, hypoimmunogenicity in vitro and in vivo, ease of sourcing, ex vivo culture and stor- age. In particular, immune modulation is viewed as a prom- ising feature of many MSCs populations, since these cel…

Wound HealingAmniotic fluidTissue EngineeringSettore BIO/16 - Anatomia UmanaStem CellsPlacentaWharton's jellyImmune modulationInfant NewbornAmniotic membranePerinatal stem cellUmbilical cord bloodAmniotic epitheliumRegenerative medicineHumansAmniotic epithelium; Amniotic fluid; Amniotic membrane; Immune modulation; Mesenchymal stem cells; Perinatal stem cells; Placenta; Regenerative medicine; Tissue repair; Umbilical cord; Umbilical cord blood; Wharton's jellyTissue repairUmbilical cordMesenchymal stem cell
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